The Science

ARA 290, also called cibinetide, is a short peptide studied for its interaction with the innate repair receptor, a signalling complex associated with tissue protection and the resolution of inflammation.

BPC 157 is a synthetic sequence derived from a protein found in gastric juice. Research examines its role in gut barrier integrity, connective-tissue repair, and the signalling that coordinates healing.

A combination of BPC 157 and TB 500 at 5mg each, pairing two of the most-studied repair-associated peptides. Research explores whether their distinct mechanisms are complementary.

KPV is the C-terminal tripeptide fragment of alpha-MSH. Research examines its anti-inflammatory profile, particularly within the gut, and its activity independent of pigmentation signalling.

LL-37 is the only human cathelicidin-derived antimicrobial peptide. Research examines its dual role in direct microbial defence and in modulating the wider innate immune response.

Thymosin Alpha-1 is a peptide originally isolated from thymic tissue. Research examines its role in the maturation of T-cells and in coordinating a balanced immune response.

TB 500 is a synthetic fragment of thymosin beta-4. Research focuses on its relationship with actin, the structural protein underpinning cell movement, and with the migration of repair cells.

KLOW combines four compounds studied across repair and renewal: TB 500, BPC 157, GHK-Cu, and KPV. The inclusion of GHK-Cu gives it a foot in both the Foundation and Longevity families.

DSIP is a nonapeptide first identified for its association with delta-wave sleep. Research examines its relationship with sleep architecture and with stress-hormone regulation.

Selank is a synthetic analog of the immunomodulatory peptide tuftsin. Research examines its role in emotional balance and stress modulation, and its profile as a non-sedating anxiolytic candidate.

Semax is a synthetic fragment derived from ACTH, modified so it carries no corticotropic activity. Research examines its role in mental clarity, focus, and cognitive resilience.

Epithalon is a synthetic tetrapeptide studied for its potential role in cellular longevity and biological-rhythm pathways. Research explores its relationship with telomere biology and pineal signalling.

GHK-Cu is a copper-binding tripeptide studied for its role in skin, connective-tissue, and cellular renewal. Its recovery profile gives it a crossover into Foundation.

Glow combines BPC 157, TB 500, and GHK-Cu, pairing two repair-associated peptides with the copper peptide most studied for skin and connective-tissue renewal.

MOTS-c is a peptide encoded in mitochondrial DNA. Research examines its role as a signal between the mitochondria and the nucleus, particularly under metabolic stress.

NAD+ is a coenzyme central to how cells convert fuel into usable energy. Research examines its role in redox reactions, mitochondrial output, and the repair pathways associated with biological aging.

SS-31, also known as elamipretide, is studied for its affinity for the inner mitochondrial membrane. Research focuses on cardiolipin, a phospholipid central to mitochondrial efficiency.

Glutathione is a tripeptide antioxidant produced in every cell. Research examines its role in redox defence, detoxification pathways, and immune function, the last giving it a Foundation crossover.

5-Amino-1MQ is a small molecule studied as an inhibitor of nicotinamide N-methyltransferase, an enzyme associated with fat-cell metabolism and cellular NAD+ availability.

AOD 9604 is a synthetic peptide derived from the C-terminal fragment of human growth hormone, isolated for research into fat metabolism without the broader activity of the full hormone.

Cagrilintide is a long-acting amylin analog studied for its role in satiety signalling, a mechanism distinct from, and often researched alongside, the incretin pathway.

SLU-PP-332 is studied as an agonist of estrogen-related receptors, a family associated with the metabolic adaptations that follow endurance exercise.

Retatrutide is studied as a triple agonist at the GLP-1, GIP, and glucagon receptors. Research examines whether engaging all three affects metabolic regulation differently to dual or single agonists.

Semaglutide is a long-acting GLP-1 receptor agonist. Research examines its role in glucose-dependent insulin signalling, gastric emptying, and the central pathways registering satiety.

Tirzepatide is studied as a dual agonist at the GIP and GLP-1 receptors. Research examines whether combining the two incretin pathways differs from GLP-1 agonism alone.

CJC-1295 without DAC, also called modified GRF 1-29, is a growth-hormone-releasing hormone analog with a short half-life, studied specifically for preserving the body's natural pulsatile release pattern.

This combination pairs a GHRH analog with a selective growth-hormone secretagogue, studied for whether engaging two complementary steps in the release cascade differs from either alone.

IGF-1 is the primary mediator of growth hormone's effects. Research examines its role in anabolic signalling, tissue growth, and the pathways downstream of the growth-hormone axis.

Ipamorelin is a selective growth-hormone secretagogue. Research examines it specifically for its selectivity, releasing growth hormone with minimal effect on cortisol or prolactin.

Tesamorelin is a stabilised growth-hormone-releasing hormone analog. Research examines its role in endogenous GHRH signalling and its association with visceral adipose tissue.

HCG is a glycoprotein hormone studied for its activity at the luteinising hormone receptor, and for its role in research on the hypothalamic-pituitary-gonadal axis.

Kisspeptin sits at the top of the reproductive hormone cascade. Research examines its role in initiating GnRH release, and the overlap between that signalling and circuits tied to desire.

PT-141 is studied for its role in the signalling pathways tied to desire and motivation. Research focuses on central melanocortin receptors rather than the vascular system.