HCG

HCG, or human chorionic gonadotropin, is a glycoprotein hormone studied for its activity at the luteinizing hormone receptor. It is a frequent subject of research on the hypothalamic-pituitary-gonadal axis, the hormonal system that regulates reproductive hormone production. Published reviews discuss its role in secondary hypogonadism, male infertility and pubertal induction, making it one of the better-documented compounds in reproductive endocrinology research.

Research describes HCG as structurally similar enough to luteinizing hormone to act at the same receptor. Because of this similarity, it has been studied for its ability to stimulate downstream endogenous hormone production. Investigators have explored it in the context of maintaining production within the reproductive hormone axis, particularly in settings where the body's own luteinizing hormone signalling is reduced or suppressed.

Published literature has examined HCG in the management of secondary hypogonadism and male infertility, pubertal induction in males with hypogonadotropic hypogonadism, and recovery from anabolic steroid-induced hypogonadism. Reviews have also discussed it among non-testosterone approaches to male hypogonadism and in relation to preserving spermatogenesis alongside testosterone replacement. A systematic review and meta-analysis has assessed gonadotropins for pubertal induction.

One published study specifically examined the safety of HCG monotherapy among men with previous exogenous testosterone use. Detailed adverse event rates are not summarized in the cited study titles, so specific findings should be taken from the full publications. Because HCG acts directly on the reproductive hormone axis, hormonal effects are a central consideration in how research protocols are designed and monitored.

Research protocols have used around 500 IU per administration, 3 times per week, in 8-week blocks followed by 4 weeks off, with subcutaneous administration described. These figures reflect reported research protocols only and are not recommendations. Each CoreX order ships with a protocol guide for laboratory reference, and CoreX supplies HCG for laboratory research use only.