CJC-1295 + Ipamorelin

CJC-1295 + Ipamorelin, also called CJC-1295 + IPA, is a research blend pairing CJC-1295, a long-acting analog of growth hormone-releasing hormone (GHRH), with Ipamorelin, a selective growth hormone secretagogue. The combination is studied for whether engaging two complementary steps in the growth hormone release cascade differs from using either compound alone. It is supplied for laboratory research use only.

The blend targets two receptor classes. CJC-1295 acts at the GHRH receptor (GHRH-R), the pathway through which releasing hormone signals the pituitary. Ipamorelin acts at the ghrelin receptor (GHS-R1a), a separate route that also stimulates growth hormone release. Research has explored whether this dual-pathway approach supports endogenous hormone release while preserving the natural pulsatile rhythm of secretion, rather than producing a constant signal.

A randomized controlled trial in healthy adults reported that CJC-1295 produced prolonged stimulation of growth hormone and IGF-I secretion. Ipamorelin was described in 1998 as the first selective growth hormone secretagogue. Reviews have discussed growth hormone secretagogues in body composition research, and recent sports medicine and orthopaedic reviews have examined peptides of this type in recovery and musculoskeletal contexts. Evidence for the combination specifically remains limited.

Human safety data for the combination are limited, and adverse events for the blend are not summarized in the cited studies. CJC-1295 has been reported to cause prolonged elevation of GH and IGF-I, which is relevant to monitoring in research settings. Recent reviews have assessed the safety of unapproved peptides used for musculoskeletal injury and athletic performance, and synthetic GHRH analogs are subject to anti-doping detection methods.

Research protocols have used 200–600 mcg per administration by the subcutaneous route, 5 days per week in a pre-sleep timing, arranged in 12-week blocks followed by 4 weeks off. These figures describe what protocols have used and are not recommendations. Each CoreX order ships with a protocol guide for laboratory reference.