Selank

Selank is a synthetic peptide analog of tuftsin, a naturally occurring immunomodulatory peptide. It has been studied as a candidate anxiolytic that is not associated with the sedation seen with conventional agents. Research has examined its role in emotional balance and stress modulation, as well as its position at the intersection of mood regulation and immune signaling, which reflects its tuftsin origin. It is supplied for laboratory research use only.

Research has investigated Selank for influence on GABAergic signaling, including studies in IMR-32 cells and animal models reporting changes in the expression of genes involved in GABAergic neurotransmission. It has also been studied for effects on brain-derived neurotrophic factor expression and on serotonin metabolism. Because it derives from tuftsin, researchers have also explored its effects on immune signaling, such as cytokine levels under stress conditions. These mechanisms remain under investigation.

Rodent studies have examined Selank in unpredictable chronic mild stress, chronic foot-shock stress, social stress, and morphine withdrawal models. One rat study reported that Selank enhanced the anxiety-reducing effect of diazepam. A connectomic study examined its effects alongside the related peptide Semax. In humans, a small randomized controlled trial examined Selank in the context of anxiety disorders. Overall, the evidence base is largely preclinical, and larger human studies are lacking.

Human safety data for Selank are limited, and adverse events are not summarized in the cited studies. The available research is mostly from cell and animal models, with only a small clinical trial in anxiety disorders. A rat study reporting that Selank enhanced the anxiety-reducing effect of diazepam suggests that interactions with GABAergic agents are a relevant consideration for researchers designing protocols. A full safety profile has not been established.

Research protocols have used 500 to 2,000 mcg per administration, given once daily in the morning by the subcutaneous route, in 4-week blocks followed by 4 weeks off. These figures describe what research protocols have used and are not recommendations. Each CoreX order ships with a protocol guide for laboratory reference. Selank is sold for research use only and is not intended for human consumption.