Sermorelin

Sermorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) that targets the GHRH receptor (GHRH-R). It has been reviewed in the literature for its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency, and it has been discussed as an approach to adult-onset growth hormone insufficiency. CoreX supplies Sermorelin for laboratory research use only.

Sermorelin is classed as a GHRH receptor (GHRH-R) agonist. It binds the receptor through which endogenous growth hormone-releasing hormone signals the pituitary to release growth hormone. Because it acts upstream of growth hormone rather than supplying the hormone itself, it has been discussed in research as an alternative approach to studying growth hormone insufficiency. Research protocols have typically used the subcutaneous route.

The main body of published work concerns the diagnosis and treatment of idiopathic growth hormone deficiency in children, along with commentary on adult-onset growth hormone insufficiency. Exploratory research has examined Sermorelin as a potential agent in recurrent glioma. Analytical studies have addressed detection of synthetic GHRH analogs, their enzymatic and serum stability, and PEGylation of GHRH analogues as a strategy to modify their properties.

Adverse events are not summarized in the cited studies, and human safety data outside pediatric growth hormone deficiency research are limited. Reviews of peptide use in sport and bodybuilding discuss GHRH-related compounds in the context of doping, and synthetic GHRH analogs are targets of anti-doping detection methods. Stability studies have characterized how GHRH-related peptides degrade in enzymatic and serum conditions, which is relevant to sample handling in laboratory work.

Research protocols have used 200–500 mcg per administration, 5 days per week in the evening, in 12-week blocks followed by 4 weeks off, via the subcutaneous route. These figures describe what published or reported research protocols have used and are not recommendations. Each CoreX order ships with a protocol guide for laboratory reference.