SLU-PP-332

SLU-PP-332 is a synthetic research compound studied as an agonist of the estrogen-related receptors (ERRα, ERRβ and ERRγ). This receptor family is associated with the metabolic adaptations that follow endurance exercise, which is why SLU-PP-332 is frequently described in the literature as an exercise mimetic. Current research on the compound is preclinical, consisting of animal and cell-based studies rather than human clinical trials.

Research investigates SLU-PP-332 as a pan-ERR agonist, meaning it has been studied for activity across the estrogen-related receptors that govern oxidative metabolic programmes. Studies have examined its effects on mitochondrial biogenesis and on the shift toward oxidative, fat-burning metabolism typically seen in endurance-trained tissue. One published study reported that the acute aerobic exercise response it induced in animals was dependent on ERRα.

Published animal studies have examined SLU-PP-332 in relation to aerobic exercise capacity, metabolic syndrome, mitochondrial dysfunction and inflammation in the aging kidney, and cardiac fatty acid metabolism in heart failure models. A pilot study has also explored ERR targeting against age-related muscle atrophy linked to physical inactivity. Chemical optimization work has used SLU-PP-332 as a starting point to gain further insight into estrogen-related receptor signaling.

Human safety data for SLU-PP-332 are limited, as no controlled human studies are available. Adverse events are not summarized in the cited animal studies. Analytical chemistry groups have characterized its in vitro metabolites for doping-control purposes, reflecting interest from anti-doping laboratories in detecting ERR agonists described as having doping potential. Its long-term effects in humans have not been established.

Research protocols have used 500 to 1,500 mcg per administration by the subcutaneous route, once daily in the morning in a fasted state, in 8-week blocks followed by 4 weeks off. These figures describe what protocols have used and are not a recommendation. Each CoreX order ships with a protocol guide for laboratory reference.